Solubility of theophylline in water

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WebThe solubility of theophylline in mixed solvents consisting of dioxane and water was determined at 25 +/- 0.1 degrees. The solubilities across this range of polar solvents were back-calculated using a technique involving an interaction energy term, W. WebJun 16, 2024 · From the observation, the Theophylline is more soluble in sodium salicylate hydrotrope than other three hydrotropes. Since it is a water soluble molecular structure …

Theophylline - Fat or water soluble? : r/chemistry - Reddit

WebThe solubility of the compound in water at 30 degrees (0.047 mg/ml) is 180-fold lower than that of theophylline (8.40 mg/ml). The complex is relatively stable in the alkaline pH range, but it hydrolyzes, releasing theophylline in acidic environments. The rate of theophylline release is pH dependent. WebTheophylline is a cyclic phosphodiesterase inhibitor. It antagonizes Adenosine A Receptors and weakly inhibits alkaline phosphodiesterases and 5′-nucleotidase. ... Soluble in water (8.3 g/l) at 20° C, 0.1 M NaOH, 0.1 M HCl, ethanol (moderately), DMSO, alkali hydroxides, ammonia, dilute hyrochloric acid, nitric acid, ... flameworking classes seattle

Extended Hildebrand Solubility Approach: methylxanthines in …

WebDec 7, 2024 · Theophylline salts — Several so-called "salts” of theophylline had been developed as attempts to increase water solubility (8 mg/mL at 25ºC) and improve absorption. While salts of theophylline may be formed with a base at high pH, theophylline is only slightly ionized at physiological pH (pK a = 8.8). WebTheobromine solubility was studied in dioxane-water mixtures, a solvent system that was investigated earlier for the solubility of theophylline and caffeine. Solubilities were calculated in these polar systems by a regression method, based on an extension of the Hildebrand-Scatchard equation of regular solution theory. WebC s is the solubility of theophylline and k is the pH of the theophylline solution. The results are shown in Table 4.From the table,it is seen that, the solubility of theophylline increases … can pot belly pigs grow tusks

Theophylline - an overview ScienceDirect Topics

Dissolution of theophylline monohydrate and anhydrous …

WebMar 4, 2010 · A homogeneous phase of IL and water was obtained by heating, while cooling of the homogeneous liquid mixture produced phase separation due to the decreased solubility. Briefly, 45 μL of [HMIM] [PF 6 ] was added to about 10 mL of a water sample, and this was then heated to 70 ºC, which enabled the IL to completely dissolve in water. WebTheophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4.* (phosphoric … can pot belly pigs swimWebCaffeine, theobromine, and theophylline are all more fat soluble than they are water soluble. 5 mo. ago. Thank you! Does the extra methyl group on caffeine (as opposed to theophylline, theobromine and paraxanthine) not make a difference? Patrick26. The presence or absence of that methyl group does affect the solubilities, but they are still ... flameworking oxygen concentrators

"WebSolubility. Soluble in water (1.0 g/120 ml), ethanol (1.0 g/80 ml), chloroform (1.0 g/110 ml), hot water, ... and potassium salts and a large number of less basic salts and/or … " - Solubility of theophylline in water

Solubility of theophylline in water

Measurement and Correlation of Solubility of Theobromine, …

Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in … WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was …

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WebApr 14, 2024 · Purpose Nitrofurantoin is an effective antibacterial drug for the treatment of lower urinary tract infection. However, the anhydrate form can easily transform to the less soluble hydrate form (monohydrate) during dissolution, resulting in a reduction of dissolution rate and oral bioavailability. Therefore, inhibition of phase transformation is … WebAug 24, 2024 · Solubility is a very important property of drugs involved in purification processes and the different pharmaceutical dosage form design stages. Otherwise, …

WebOct 9, 2013 · In this paper, the influence of polymorphs on the transformation water activity that corresponds to the transformation between hydrate and anhydrate of theophylline was investigated. Theophylline is known to exist either as anhydrates or a monohydrate. The transformation water activities of theophylline form II and IV were determined … WebJan 1, 2015 · Theophylline is dimethylxanthine which is closely related chemically to caffeine (Fig. 1 ). Like caffeine, theophylline is sparingly soluble in water (7 g/l). The logP value of theophylline is –0.02 giving the unionized form sufficient lipid solubility to diffuse passively through cell membranes. Theophylline is a weak acid (pKa 8.8).

WebJun 23, 2009 · The enthalpies of solution $$ \\Updelta_{sol}^{{}} H_{m}^{{}} $$ of polymorphic forms I and II of theophylline in water at 298.15 K using the isoperibol solution calorimeter have been determined in the range of concentration (0.311–1.547) · 10−3 /mol · kg−1. The enthalpies of hydration $$ \\Updelta_{hyd}^{{}} H_{m}^{o} $$ were determined … WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was …

Web[Water soluble theophylline] [Water soluble theophylline] G Med Mil. Jul-Aug 1955;105(4):369-73. [Article in Italian] Author R RUGGIERI. PMID: 13277851 No abstract …

WebTheophylline (3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione ); anhydrous, ≥ 99%, powder; can pot belly pigs inbreedWebSolubility: Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in ammonia Sweetman (2002). Ionization Constant: Value: Salt: Conditions: Reference: Comments: pKa: 8.77: monohydrate: 25° O'Neil et al (2001) flamework classesWebHowever, theophylline is only sparingly soluble in water and alcohol. The solubility of theophylline in water is 5.5 mg/mL, whereas in methanol and ethanol is 0.699 mg/mL and … can pot give you diarrheaWebAug 1, 1994 · The results were treated on the basis of the extended Hildebrand solubility approach considering interaction terms. An equation has been obtained for predicting the … can potential employer request salary historyWebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. It was found that the solubility of theobromine, theophylline, … can potential energy be converted to thermalWebJul 8, 2024 · Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured … flameworking projectsWebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ... can potential renters review you on airbnb