Mal2 and cancer

Author: yvrt

August undefined, 2024

WebHowever, the function and mechanism of KK-LC-1, a member of the CTA family, in breast cancer are still unclear. Methods Bioinformatic tools, immunohistochemistry, and western blotting were utilized to detect the expression of KK-LC-1 in breast cancer and to explore the prognostic effect of KK-LC-1 expression in breast cancer patients. Web4 feb. 2024 · Bladder cancer is one of the most common malignancies of the urinary tract and can be divided into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Although the means of diagnosis and treatment have continually improved in recent years, the recurrence rate of bladder cancer remains high, and …

MAL2 drives immune evasion in breast cancer by suppressing …

Web21 mei 2024 · The myelin and lymphocyte protein 2 (MAL2) is upregulated in multiple cancers at the transcriptional level. However, the exact role of MAL2 in pancreatic cancer remains elusive. In this study, we demonstrated that MAL2 protein and mRNA levels were upregulated in pancreatic cancer. WebRabbit polyclonal MAL2 antibody. Validated in IHC and tested in Mouse. Cited in 1 publication(s). Independently reviewed in 2 review(s). ... Human Tissue sections (breast cancer metastasis) Antigen retrieval step. Heat mediated - Buffer/Enzyme Used: Citrate, pH 6.0. Permeabilization. No. Specification. breast cancer metastasis. charles babbage reddit

The four-transmembrane protein MAL2 and tumor protein D52

WebMAL2 (Mal, T Cell Differentiation Protein 2), a transmembrane protein of the MAL proteolipid family, is upregulated in a number of malignancies, such as breast, colorectal, pancreatic, or ovarian... Web29 nov. 2024 · A total of 6/16 left-sided tumors from MAL2 were biofilm positive (37.5%), while all seven right-sided tumors were biofilm positive (100%). Biofilm results for MAL2 were then combined with the... Web2 okt. 2024 · Materials and methods: We downloaded and analyzed the MAL2 expression in The Cancer Genome Atlas (TCGA) database. Real-time quantitative polymerase … charles babbage profession

MAL2 promotes proliferation, migration, and invasion …

Targeting KK-LC-1 inhibits malignant biological behaviors of triple ...

WebMAL2 is recognized as an oncogene in some cancer types, such as breast cancer, ovarian carcinoma, and pancreatic ductal adenocarcinoma. 15–18 However, Lopez-Coral et al 19 recently found that MAL2 protein levels were decreased in malignant tissues compared to benign tissues in hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and renal … WebInterested in issues relevant to cancer research and the global cancer burden, with a particular emphasis in low- and middle-income countries. Ph.D. in cellular & microbial biology with 10+ years ... charles babbage research centreWeb28 dec. 2024 · The MAL2 gene is expressed in various tumor tissues, including breast cancers, and increased levels of MAL2 in tumor cells are associated with a reduction in survival ( Bhandari et al., 2024; Li et al., 2024; Shehata et al., 2008 ). However, little is known about the functions of MAL2 in tumor cells. charles babbage road cambridge

"Web29 mrt. 2024 · MAL2 has a role in promoting proliferation, migration, and invasion through regulating epithelial-mesenchymal transition in breast cancer cell lines Up-regulation of … " - Mal2 and cancer

Mal2 and cancer

IGFBP3mRNA expression in benign and malignant breast tumors

WebKey features and details Rabbit polyclonal to MAL2 Suitable for: ELISA, ICC, WB Reacts with: Human Isotype: IgG You may also be interested in Secondary Goat Anti-Rabbit IgG H&L (HRP) (ab205718) Primary Anti-IDH1 antibody [IDH1/1152] - BSA and Azide free (ab212470) Primary Anti-c-Myc antibody [Y69] - ChIP Grade (ab32072) WebClin Cancer Res. 2006;12(23):6937–6945. 14. Byrne JA, et al. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovari-an carcinoma, but differentially associated with histological subtype and patient outcome. BMC Cancer. 2010;10:497. 15. Hu Q, et al. Oncogenic lncRNA downregu-lates cancer cell antigen presentation and

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Web24 sep. 2024 · MAL2Was Closely Associated with TP53and APCMutations in CRC To identify novel metastasis-oriented driver genes in CRC, we first identified the differentially expressed genes (DEGs) in the four American Joint … Webgression of gastric cancer by acting as a miR-206 sponge. However, whether the lncRNA-RMRP executed its function in bladder cancer remains largely unclear. In this work, we aimed to detect the expression of lncRNA RMRP in the bladder cancer and explored the possible mechanism of lncRNA RMRP affecting the malignant activity of bladder cancer.

Web17 jan. 2024 · Recent studies have reported that T-cell differentiation protein 2 (MAL2) is an important regulator in cancers. Here, we downloaded data from multiple databases … Web4 jan. 2024 · Notably, MAL2 expression was associated with poor prognosis of breast cancer, and its downregulation enhanced CD8+ T cell recognition of breast cancer …

Web28 feb. 2024 · In breast cancer the gene MAL2, which encodes a transmembrane protein associated with protein endocytosis, promotes the turnover of pMHC-I complexes by modulating the interaction between RAB7 and MHC-I . MAL2 plays a critical role in the endocytosis-mediated protein degradation of the MHC-I complex and downregulates … Web23 jun. 2014 · Funding: This work was supported by NIH R01 HD067721 (to SLY and BAL), NIH R01 HD057873 and American Cancer Society Research Grant RSG-12-084-01-TBG (to JWJ), and the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning …

Web30 sep. 2024 · MAL2 promotes the endocytosis of tumor antigens via direct interaction with the MHC-I complex and endosome-associated RAB proteins. In preclinical models, depletion of MAL2 in breast tumor cells profoundly enhanced the cytotoxicity of tumor-infiltrating CD8+ T cells and suppressed breast tumor growth, suggesting that MAL2 is a potential …

WebIn this review, following a brief description on how cancer stem cells (CSCs) and their microenvironment contribute to tumor preservation and heterogeneity, we summarize the current literature regarding the molecular signature of BCSCs either localized in the primary tumor or circulating in the blood of breast cancer patients. harry potter book pdfWebMAL2 Gene - Somatic Mutations in Cancer Actionability v8 is now available for download Gene GRCh38 · COSMIC v97 Gene view The gene view histogram is a graphical view of … charles babbage schoolhttp://yuxiqbs.cqvip.com/Qikan/Article/Detail?id=9373736 harry potter book of spells gameWebSTK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs to the NAK kinase family that has an atypical activation loop architecture. As a membrane-associated … charles babbage roadWebMAL2 - Explore an overview of MAL2, with a histogram displaying coding mutations, full tabulated details of all associated variants, ... This gene does not have a cancer hallmark. You can see more information about hallmarks. COSMIC gene MAL2 (COSG614891) Genomic coordinates 8: ... charles babbage religionWeb17 aug. 2024 · Lung cancer is the most lethal type of cancer in the United States and worldwide. In the United States, it is predicted that 222,500 new lung cancer patients will be diagnosed, and 155,870 people will die of lung cancer in 2024. 1 The death rate from lung cancer is 25%, the highest among all types of cancer. harry potter book priceWeb4 apr. 2024 · Once MAL2 was identified as a main suspect, the group studied its effects on breast cancer cell growth and its interactions cells of the immune … harry potter book pages printable